How to Choose the Optimal Starting Dose of Clomiphene Citrate (50 or 100 mg per Day) for a First Cycle of Ovulation Induction in Anovulatory PCOS Women?

Research question: Clomiphene citrate (CC) is one of the first-line treatments for ovulation induction in women with anovulatory polycystic ovary syndrome (PCOS). However, nearly 1 out 2 resistant to 50 mg/day CC. The objective this study investigate clinical, biological, and/or ultrasound factors that may predict resistance CC first cycle treatment PCOS. This would make it possible identify PCOS patients whom dose 100 be offered as cycle. Design: A retrospective and monocentric was conducted on 283 who required use (903 cycles). Results: During treatment, 104 (36.8%) were Univariate regression analysis showed resisted had significantly higher BMI, waist circumference, serum levels AMH, total testosterone, Δ4-androstenedione, 17-OHP, insulin (p < 0.05), compared ovulating dose. Serum SHBG lower 0.05). After multivariate analysis, only AMH remained statistically significant = 0.01 p 0.001, respectively). areas under ROC curves weak (0.59 0.68, Conclusion: are two parameters associated risk no satisfactory thresholds have been established mg